Тип публикации: статья из журнала
Год издания: 2020
Идентификатор DOI: 10.1515/revneuro-2020-0077
Ключевые слова: brain plasticity, early life stress, memory, neurogenesis, oxytocin
Аннотация: Early life stress (ELS) is one of the most critical factors that could modify brain plasticity, memory and learning abilities, behavioral reactions, and emotional response in adulthood leading to development of different mental disorders. Prenatal and early postnatal periods appear to be the most sensitive periods of brain developmПоказать полностьюent in mammals, thereby action of various factors at these stages of brain development might result in neurodegeneration, memory impairment, and mood disorders at later periods of life. Deciphering the processes underlying aberrant neurogenesis, synaptogenesis, and cerebral angiogenesis as well as deeper understanding the effects of ELS on brain development will provide novel approaches to prevent or to cure psychiatric and neurological deficits caused by stressful conditions at the earliest stages of ontogenesis. Neuropeptide oxytocin serves as an amnesic, anti-stress, pro-angiogenic, and neurogenesis-controlling molecule contributing to dramatic changes in brain plasticity in ELS. In the current review, we summarize recent data on molecular mechanisms of ELS-driven changes in brain plasticity with the particular focus on oxytocin-mediated effects on neurogenesis and angiogenesis, memory establishment, and forgetting. © 2020 Walter de Gruyter GmbH, Berlin/Boston 2020.
Журнал: Reviews in the Neurosciences
ISSN журнала: 03341763
Издатель: De Gruyter Open Ltd