Evaluation of antitumor activity of rubomycin deposited in absorbable polymeric microparticles


Тип публикации: статья из журнала

Год издания: 2008

Идентификатор DOI: 10.1007/s10517-008-0091-9

Ключевые слова: microencapsulation, rubomycin, absorbable polymers, polyhydroxybutyrate, Ehrlich's ascitic carcinoma, poly(3 hydroxybutyric acid), polymer, animal cell, animal experiment, animal model, antineoplastic activity, article, Bagg albino mouse, cancer inhibition, cancer mortality, cancer survival, controlled study, drug delivery system, Ehrlich ascites tumor, mouse, nonhuman, polymerization, survival rate, tumor cell, tumor volume, Absorption, Animals, Antibiotics, Antineoplastic, Carcinoma, Ehrlich Tumor, Daunorubicin, Hydroxybutyrates, Mice, Mice, Inbred BALB C, Microspheres, Polyesters, Mus

Аннотация: An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric micropartПоказать полностьюicles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections.

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Выпуск журнала: Vol. 145, Is. 3

Номера страниц: 358-361

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER


  • Shishatskaya E.I. (Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences)
  • Voinova O.N. (Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences)
  • Khlebopros R.G. (Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences)
  • Goreva A.V. (Siberian Federal University)
  • Volova T.G. (Siberian Federal University)
  • Inzhevatkin E.V. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science)

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