Тип публикации: статья из журнала

Год издания: 2019

Идентификатор DOI: 10.1016/j.mgene.2018.10.010

Ключевые слова: Psoriatic disease, psoriasis, psoriatic arthritis, Haplotype Cytokines

Аннотация: Psoriasis (PS) and psoriatic arthritis (PsA) are subtypes of psoriatic disease (PD), a chronic inflammatory disorder with predominantly cutaneous manifestations. PsA is developed in approximately one third of patients with PS. These two phenotypes are immune-mediated diseases with different heredity that might in part be explained Показать полностьюby different genetic factors. We carried out an analysis of association between haplotypes of cytokine genes (TNFA, IL4 and IL10) and PD in Russians from East Siberian region of Russia. The haplotypes were not found to be associated with either PS or PsA. However, meta-analyses with published data suggested associations between PS and IL4 rs2243250 and TNFA rs1800629 polymorphisms, while PsA was found to be associated with IL4 rs2243250 only. The results provide further insight into understanding of genetic factors predisposing to PD.

Журнал: Meta Gene

Выпуск журнала: Т. 19

Номера страниц: 60-64

ISSN журнала: 22145400

• Smolnikova M.V. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science)
• Freidin M.B. (Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia)
• Barilo A.A. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science)
• Smirnova S.V. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science)

• Ядро РИНЦ (eLIBRARY.RU)