Sulfation of Betulin with Chlorosulfonic Acid in Pyridine : научное издание

Описание

Тип публикации: статья из журнала

Год издания: 2020

Идентификатор DOI: 10.17516/1998-2836-0197

Ключевые слова: betulin, sulfation, chlorosulfonic acid, pyridine, betulin 3,28-disulfate identification, ir-, raman- and c-13 nmr-spectroscopy, scanning electron microscopy, thin-layer chromatography, micelle formation, 28-disulfate, betulin 3, identification ir-, raman- and 13c nmr-spectroscopy

Аннотация: It was found that when betulin is sulfated with chlorosulfonic acid in pyridine medium, 3,28-disulfate of betulin is formed in a stable salt form. Under optimal synthesis conditions: temperature 70 degrees C, duration 2 hours, molar ratio betulin / chlorosulfonic acid 4.0, betulin is completely converted into betulin 3.28-disulfateПоказать полностью. The structure and composition of betulin 3,28-disulfate were confirmed by elemental analysis, IR, Raman and 13C NMR spectroscopy. Betulin 3,28-disulfate was isolated both in the form of an unstable H + -form and in a stable forms of sodium and pyridinium salts. Sodium salt of 3,28- disulfate is a needle-like crystals collected in cobweb-like aggregates. The sodium salt of 3,28-disulfate has mycellar properties, the critical concentration of mycellar formation is 0.23 mmol / L. It was found that when betulin is sulfated with chlorosulfonic acid in pyridine medium, 3,28-disulfate of betulin is formed in a stable salt form. Under optimal synthesis conditions: temperature 70 °C, duration 2 hours, molar ratio betulin / chlorosulfonic acid 4.0, betulin is completely converted into betulin 3.28-disulfate. The structure and composition of betulin 3,28-disulfate were confirmed by elemental analysis, IR, Raman and 13C NMR spectroscopy. Betulin 3,28-disulfate was isolated both in the form of an unstable H + -form and in a stable forms of sodium and pyridinium salts. Sodium salt of 3,28-disulfate is a needle-like crystals collected in cobweb-like aggregates. The sodium salt of 3,28-disulfate has mycellar properties, the critical concentration of mycellar formation is 0.23 mmol / L. © Siberian Federal University. All rights reserved

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Издание

Журнал: JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY

Выпуск журнала: Vol. 13, Is. 3

Номера страниц: 447-459

ISSN журнала: 19982836

Место издания: KRASNOYARSK

Издатель: SIBERIAN FEDERAL UNIV

Персоны

  • Vasilyeva Natalia Yu (FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Krasnoyarsk, Russia; Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Kazachenko Alexander S. (FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Krasnoyarsk, Russia; Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Malyar Yuriy N. (FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Krasnoyarsk, Russia; Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Kuznetsov Boris N. (FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, Krasnoyarsk, RussiaSiberian Fed Univ, Krasnoyarsk, Russia)

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