Stress-induced bystander signaling as a possible factor contributing to neuronal excitability and seizure generation/epileptogenesis

Описание

Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1016/j.mehy.2016.03.008

Аннотация: We hypothesize that cell stress-caused bystander signaling induced by certain exogenous and endogenous stressors, such as ionizing radiation exposure, chemicals, tumor, or senescent cells, might contribute to neuronal excitability and synchronization, specifically to initiation of hyperexcitability, excessive synchronization and seПоказать полностьюizure generation in epileptic brain/epileptogenesis. It is suggested that bystanderly induced interconnected variations in cytosolic Ca2+, cytokines, and reactive oxygen/nitrogen species, and in activity of mitogen-activated protein kinases and nuclear factor kappa B pathways might affect neurotransmitter system, neuronal receptors and ion channels implicated in seizure generation/epileptogenesis, or modulate expression of genes associated with epileptogenesis. The mechanism suggested may, at least partly, explain the emerging evidence of association between exposures to low-dose ionizing radiation and epileptogenesis. The bystander mechanism for the generation of epilepsy might constitute new potential molecular target for the design of antiepileptic drugs. (C) 2016 Elsevier Ltd. All rights reserved.

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Издание

Журнал: MEDICAL HYPOTHESES

Выпуск журнала: Vol. 90

Номера страниц: 57-62

ISSN журнала: 03069877

Место издания: EDINBURGH

Издатель: CHURCHILL LIVINGSTONE

Персоны

  • Zakhvataev Vladimir E. (Siberian Fed Univ, Lab Biol Act Low Intens Factors, 79 Svobodny Pr, Krasnoyarsk 660041, Russia; Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Neuroinformat Dept, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands)