Тип публикации: статья из журнала

Год издания: 2007

Идентификатор DOI: 10.1134/S1068162007060027

Ключевые слова: antimicrobial peptides; branched peptides; dendrimers; pentafluorophenyl esters

Аннотация: Branched peptides E(RLAR)(2), E[E(RLAR)(2)](2), and E(KLAR)(2), E[E(KLAR)(2)](2) were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 mu M for Escherichia coli cellПоказать полностьюs, which is comparable to antimicrobial activities of temporin, magainin, and dermaseptin. The branched peptides were found not to act on human erythrocytes.

Журнал: RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Выпуск журнала: Vol. 33, Is. 6

Номера страниц: 544-548

ISSN журнала: 10681620

Место издания: NEW YORK

Издатель: MAIK NAUKA/INTERPERIODICA/SPRINGER

• Khrushchev A.Yu. (Faculty of Chemistry,Krasnoyarsk State University)
• Kashparov I.A. (Institute of Protein Research,Russian Academy of Sciences)
• Klimenko L.V. (Institute of Protein Research,Russian Academy of Sciences)
• Mitin Yu.V. (Institute of Protein Research,Russian Academy of Sciences)

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