Тип публикации: статья из журнала

Год издания: 2015

Идентификатор DOI: 10.1007/s10517-015-2785-0

Ключевые слова: antibiotics, Apoptosis, immunomodulators, innate immunity cells, Streptococcus pneumonia, bacterial enzyme, biological product, immunomodulating agent, licopid, moxifloxacin, tinrostim, unclassified drug, immunologic factor, pibenzimol, quinolone derivative, animal cell, animal experiment, antibacterial activity, Article, bacterial strain, bactericidal activity, cell death, cell function, controlled study, drug effect, immunocompetent cell, in vitro study, in vivo study, innate immunity, male, mouse, nonhuman, phagocyte, Streptococcus pneumoniae, animal, drug effects, immunomodulation, Pneumococcal Infections, Animals, Bisbenzimidazole, Fluoroquinolones, Immunity, Innate, Immunologic Factors, Mice, Phagocytes

Аннотация: Low activity of bactericidal enzymes was found in innate immunity cells infected with S. pneumonia. The death of these cells was fastened under these conditions. On the contrary, treatment with antibiotic maxifloxacin was followed by an increase in activity of bactericidal enzymes in phagocytes and induced their death via necrosis.Показать полностьюAnalysis of the therapeutic properties of immunomodulators tinrostim and licopid in combination with maxifloxacin showed that these combinations correct functional activity of cells infected with S. pneumonia. © 2015, Springer Science+Business Media New York.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 158, Is. 4

Номера страниц: 461-464

• Plekhova N.G. (G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation, School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russian Fed)
• Kondrashova N.M. (G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation, Pacific Ocean State Medical University, Ministry of Health of the Russian Fe)
• Somova L.M. (G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation, Pacific Ocean State Medical University, Ministry of Health of the Russian Federat)
• Drobot E.I. (G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation, Pacific Ocean State Medical University, Ministry of Health of the Russian Federat)
• Lyapun I.N. (G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russian Federation, Pacific Ocean State Medical University, Ministry of Health of the Russian Federat)

• Scopus