Тип публикации: статья из журнала
Год издания: 2017
Идентификатор DOI: 10.1515/revneuro-2016-0071
Ключевые слова: adult neurogenesis, angiogenesis, blood-brain barrier, neurogenic niche
Аннотация: Adult neurogenesis is one of the most important mechanisms contributing to brain development, learning, and memory. Alterations in neurogenesis underlie a wide spectrum of brain diseases. Neurogenesis takes place in highly specialized neurogenic niches. The concept of neurogenic niches is becoming widely accepted due to growing eviПоказать полностьюdence of the important role of the microenvironment established in the close vicinity to stem cells in order to provide adequate control of cell proliferation, differentiation, and apoptosis. Neurogenic niches represent the platform for tight integration of neurogenesis and angiogenesis supported by specific properties of cerebral microvessel endothelial cells contributing to establishment of partially compromised blood-brain barrier (BBB) for the adjustment of local conditions to the current metabolic needs of stem and progenitor cells. Here, we review up-to-date data on microvascular dynamics in activity-dependent neurogenesis, specific properties of BBB in neurogenic niches, endothelial-driven mechanisms of clonogenic activity, and future perspectives for reconstructing the neurogenic niches in vitro.
Журнал: Reviews in the Neurosciences
Выпуск журнала: Т. 28, № 4
Номера страниц: 397-415
ISSN журнала: 03341763
Издатель: Freund Publishing House Ltd.