Тип публикации: статья из журнала

Год издания: 2015

Идентификатор DOI: 10.15829/1560-4071-2015-10-12-18

Ключевые слова: Gene rs20455, KIF6, Mononucleotide polymorphism, MYH15, PALLD, Riskometer, Rs1010, Rs2298566, Rs3900940, Rs7439293, SNX19, Sudden cardiac death, VAMP8

Аннотация: Aim. The study of mononucleotide polymorphisms associations rs20455 gene KIF6, rs7439293 gene PALLD, rs2298566 gene SNX19, rs3900940 gene MYH15, rs1010 gene VAMP8, included into the Riskometer of ischemic heart disease of the Celera Corporation (USA), in sudden cardiac death. Material and methods. To the study the group of persons Показать полностьюincluded, died from sudden cardiac death, according to the WHO criteria (n=352, mean age — 53,3±8,9 y.), control group from matched by age and gender from DNA bank of HAPIEE, MONICA studies (n=381, mean age — 53,1±8,3 y.), adolescents group (n=296, mean age — 15,6±0,9 y.). DNA extracted via the phenol-chloroform extraction from myocardium of the dyed due to sudden cardiac death, and from venous blood of controls. Genotyping performed with Real-time PCR method using the Taq-Mancatheters technology (Applied Biosystems). Results. The prevalence of alleles rs7439293 gene PALLD, rs2298566 gene SNX19, rs3900940 gene MYH15 did not statistically significantly differ among the groups. In those died suddenly older than 50 years, there was significant decrease of carriers of GG polymorphism rs20455 gene KIF6 (9,0%) comparing to the controls (17,8%) (p=0,009, OR=0,456, 95% CI 0,256-0,810). In men older 50, died suddenly, there was significant decrease of the carriers of genotype CC (8,0%) (p=0,002, OR=0,328, 95% CI 0,159-0,678) and increase of CТ genotype (49,6%) (p=0,025, OR=1,729, 95% CI 1,084-2,758) polymorphism rs1010 gene VAMP8 comparing to the controls (21,0%, 36,3%, respectively). Conclusion. Polymorphisms rs20455 gene KIF6 and rs1010 gene VAMP8 are associated with sudden cardiac death. © 2015, Silicea-Poligraf. All rights reserved.

Журнал: Russian Journal of Cardiology

Выпуск журнала: Vol. 126, Is. 10

Номера страниц: 12-18

• Maksimov V.N. (FSBI Scientific-Research Institute of Therapy and Prevention Medicine of SD RAS, Novosibirsk, Russian Federation, SEI HPE Novosibirsk State Medical University, The Federal Agency for Healthcare and Social Development, Novosibirsk, Russian )
• Ivanova A.A. (FSBI Scientific-Research Institute of Therapy and Prevention Medicine of SD RAS, Novosibirsk, Russian Federation)
• Orlov P.S. (FSBI Scientific-Research Institute of Therapy and Prevention Medicine of SD RAS, Novosibirsk, Russian Federation, RAS Institution, The Institute of Cytology and Genetics of Siberian RAS Department, Novosibirsk, Russian Federation)
• Savchenko S.V. (SEI HPE Novosibirsk State Medical University, The Federal Agency for Healthcare and Social Development, Novosibirsk, Russian Federation, SHI Novosibirsk Regional Bureau of Forensic Medicine, Novosibirsk, Russian Federation)
• Voevoda M.I. (FSBI Scientific-Research Institute of Therapy and Prevention Medicine of SD RAS, Novosibirsk, Russian Federation, RAS Institution, The Institute of Cytology and Genetics of Siberian RAS Department, Novosibirsk, Russian Federation)

• Scopus