Тип публикации: статья из журнала
Год издания: 2014
Идентификатор DOI: 10.1007/s10517-014-2624-8
Ключевые слова: degradable polymers, poly-3-hydroxybutyrate, systems of controlled drug delivery, polymeric microparticles, experimental skin lesions, dexamethasone, diclofenac, polyester, polyhydroxyalkanoic acid, polymer, antiinflammatory agent, drug carrier, acanthosis, animal experiment, animal tissue, antiinflammatory activity, Article, burn, controlled study, mouse, nonhuman, sebaceous gland, skin biopsy, skin injury, skin necrosis, therapy, wound healing, animal, Bagg albino mouse, chemistry, injuries, skin, Wounds and Injuries, Animals, Anti-Inflammatory Agents, Drug Carriers, Mice, Mice, Inbred BALB C, Polymers
Аннотация: We studied the effects of anti-inflammatory substances incorporated in polymeric microparticles made of degradable natural polyhydroxyalkanoate polyesters on experimental skin wounds caused by chemical burns in laboratory animals. Treatment with encapsulated forms of anti-inflammatory substances (applied in gel) accelerated wound hПоказать полностьюealing in comparison with routine therapy (estimated by area of burn wound, wound healing activity, number of acanthotic cells, and number of hair and sebaceous follicles). The results showed the perspectives of usage of developed form of substances (degradable polymeric microparticles) for treatment of skin defects.
Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Выпуск журнала: Vol. 157, Is. 5
Номера страниц: 597-602
ISSN журнала: 00074888
Место издания: NEW YORK
Издатель: SPRINGER