Тип публикации: статья из журнала
Год издания: 2017
Идентификатор DOI: 10.1007/s10517-017-3741-y
Ключевые слова: GJA5, KCNN3, SCN5A, single-nucleotide polymorphism, sudden cardiac death
Аннотация: We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rsПоказать полностью1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group. © 2017, Springer Science+Business Media, LLC.
Журнал: Bulletin of Experimental Biology and Medicine
Выпуск журнала: Vol. 163, Is. 1
Номера страниц: 73-77
ISSN журнала: 00074888
Издатель: Springer New York LLC