High-throughput powder X-ray diffraction, IR-spectroscopy and ion chromatography analysis of urinary stones: A comparative study


Тип публикации: статья из журнала

Год издания: 2013

Идентификатор DOI: 10.2478/s11532-013-0335-z

Ключевые слова: Urinary stones composition, Ion chromatography, Powder X-ray diffraction, IR-spectroscopy, Hierarchical clustering

Аннотация: The instrumental qualitative analysis of urinary stones is a critical step in clinical practice and urological research. A powder X-ray diffraction, IR-spectroscopy and ion chromatography have been applied for the qualitative analysis of 20 urinary stones. Suggestions for a sample preparation and an optimal measurement strategy werПоказать полностьюe formulated. The main difficulties for the powder X-ray diffraction qualitative analysis are a limiting amount of the sample and a preferential orientation of crystals, both issues should be minimized by the special sample preparation. Urinary stones samples have been clustered into four groups using different sets of numerical input data (cation and anion content, phase composition). At the same time a high-throughput multivariate clustering has been applied for powder X-ray diffraction and IR-spectroscopy data. The multivariate whole-profile approach can be used as a tool for a high-throughput time reducing technique for clinical practice, when a quick and stable classification of samples is required. All three sets of the data can be automatically separated into three clusters: oxalate-reach, oxalate-pure and non-oxalate samples. Uricite-pure and uricite-rich samples can be easily clustered.

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Выпуск журнала: Vol. 11, Is. 12

Номера страниц: 2107-2119

ISSN журнала: 18951066

Место издания: WARSAW

Издатель: VERSITA


  • Yusenko Elena V. (Siberian Fed Univ, Dept Analyt & Organ Chem, Krasnoyarsk 660041, Russia)
  • Yusenko Kirill V. (Univ Oslo, Dept Chem, Ctr Mat Sci & Nanotechnol, N-0315 Oslo, Norway)
  • Korolkov Ilya V. (Nikolaev Inst Inorgan Chem, Dept Crystal Chem, Novosibirsk 630090, Russia)
  • Shubin Alexandr A. (Siberian Fed Univ, Dept Phys & Inorgan Chem, Krasnoyarsk 660041, Russia)
  • Kapsargin Fedor P. (Vojno Yasenetsky Krasnoyarsk Med State Univ, Dept Urol Androl & Sexol, Krasnoyarsk 660022, Russia)
  • Efremov Alexandr A. (Siberian Fed Univ, Dept Analyt & Organ Chem, Krasnoyarsk 660041, Russia)
  • Yusenko Maria V. (Univ Munster, Fac Med, Inst Mol Tumor Biol IMTB, D-48149 Munster, Germany)