Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1007/s10517-014-2630-x

Ключевые слова: breast cancer, immunohistochemistry, estrogen receptor, Ki 67 antigen, progesterone receptor, protein bcl 2, protein p53, tumor marker, adult, age distribution, aged, Article, cancer incidence, cancer patient, cancer prognosis, cell proliferation, ethnic difference, female, histopathology, human, human tissue, indigenous people, major clinical study, protein expression, tumor differentiation, breast tumor, metabolism, middle aged, USSR, Breast Neoplasms, Commonwealth of Independent States, Humans, Ki-67 Antigen, Proto-Oncogene Proteins c-bcl-2, Receptors, Estrogen, Receptors, Progesterone, Tumor Markers, Biological, Tumor Suppressor Protein p53

Аннотация: The results of histological studies of operation material from 294 women with breast cancer and immunohistochemical detection of estrogen and progesterone receptors and evaluation of proliferative activity (Ki-67) and expression of proteins p53 and bcl-2 were analyzed. Breast cancer was more incident (60%) in nonindigenous residentПоказать полностьюs of the Sakha Republic (Yakutia) than in representatives of the indigenous population (40% cases). The disease was more incident in women aged 50-59 years (32.6%) and 60-69 years (21.8%) irrespective of the ethnic appurtenance. The findings indicated the most informative criteria of mammary tumor malignancy: low expression of estrogen and progesterone receptors, high expression of Ki-67 and p53, and low expression of bcl-2. © 2014, Springer Science+Business Media New York.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 157, Is. 5

Номера страниц: 623-627

• Kirillina M.P. (Yakut Research Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation, Medical Institute, M. K. Ammosov North-Eastern Federal University, Yakutsk, Russian Federati)
• Loskutova K.S. (Yakut Research Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation, Medical Institute, M. K. Ammosov North-Eastern Federal University, Yakutsk, Russian Federati)
• Lushnikova E.L. (Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation)
• Nepomnyashchikh L.M. (Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russian Federation)

• Scopus