Strong Prevalence of the Function over Taxonomy in Human tRNA Genes


Тип публикации: доклад, тезисы доклада, статья из сборника материалов конференций

Конференция: 9th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2022

Год издания: 2022

Идентификатор DOI: 10.1007/978-3-031-07802-6_15

Ключевые слова: clustering, elastic map, structure, triplet frequency

Аннотация: Human DNA contains many genes encoding transfer RNAs. These genes differ significantly in their primary structure, nucleotide sequence, within the same organism. This study aims to reveal the relationship between the structure of the tRNA gene sequence and the amino acids carried by the tRNA corresponding to their genes. Raw tRNA gПоказать полностьюene sequences were used as data. After preliminary preparation, the data were analyzed by nonlinear method of dimensionality reduction and data clusterization called elastic maps. The method application revealed the data structure (triplet frequency composition) and desired interplay between the structure and function (the type of amino acid residue to be transferred) over the set of human transfer RNA genes. Some deviations in the distribution of the isodecoders are discussed. © 2022, Springer Nature Switzerland AG.

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Журнал: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Выпуск журнала: Vol. 13347 LNBI

Номера страниц: 169-178

ISSN журнала: 03029743

Издатель: Springer Science and Business Media Deutschland GmbH


  • Nedorez Y. (School of Fundamental Biology and Biotechnology of Siberian Federal University, Krasnoyarsk, Russian Federation)
  • Sadovsky M. (Institute of Computational Modelling of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russian Federation, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation, Federal Siberian Research and Clinical Center of FMBA of Russia, Krasnoyarsk, Russian Federation)

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