Тип публикации: статья из журнала
Год издания: 2014
Идентификатор DOI: 10.1134/S000635091404023X
Ключевые слова: controlled drug delivery systems, electrokinetic potential, microparticles, poly-3-hydroxybutyrate, resorbable polymers
Аннотация: The study investigates electrokinetic potentials of microparticles prepared from biodegradable poly-3-hydroxybutyrate depending upon the method of preparation employed and taking into account the size of particles maintained in liquid media. The ?-potential of microparticles prepared from emulsion by solvent evaporation method was Показать полностью?20 mV; the ?-potential of microparticles prepared by spray drying was reduced to ?95 mV. The value of ?-potential was influenced by drug loading into microparticles; the drug-loaded microparticles maintained in balanced phosphate buffer for 30 days had higher physical stability than those without drug loading. © 2014, Pleiades Publishing, Inc.
Журнал: Biophysics (Russian Federation)
Выпуск журнала: Vol. 59, Is. 4
Номера страниц: 561-567