Тип публикации: статья из журнала
Год издания: 2015
Идентификатор DOI: 10.15690/vramn.v70.i4.1415
Ключевые слова: Malignant transformation epithelial cells, Wnt/?-catenin signaling, ?-catenin
Аннотация: The article presents the data on the structure and mechanisms of ?-catenin functioning. The basic aspects of the role of ?-catenin in malignant transformation have been studied at various tumors. Primary structure of ?-catenin allows it to interact with many factors and ligands, including transcription factors, ?-catenin, cadherin,Показать полностьюAxin, Rho family GTPases, Bcl9 et al. This interaction is the base for ?-catenin's intracellular multifunctioning. The review presents data on the participation of ?-catenin in the mechanisms of adhesion, regulation of RNA metabolism, formation contacts with the cytoskeleton and its role in the canonical Wnt signaling pathway, marked examples pro-inflammatory and anti-inflammatory effects of ?-catenin. The ?-catenin involvement in malignant transformation and progression of certain tumors is not in doubt. The data on the changes in ?-catenin expression in the given examples of colon cancer, prostate cancer, different forms of thyroid cancer and hepatocellular carcinoma are presented with the prospects of its use as a marker and a predictor of malignant transformation. Continued research in this area will not only make use of ?-catenin as a potential predictor of malignant tumors, but also to develop approaches to targeted therapy.
Журнал: Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
Выпуск журнала: Vol. 70, Is. 4
Номера страниц: 475-483