Effects of Cisplatin on Lymphocyte Structure and Functions in Mice with Ehrlich Ascitic Carcinoma


Тип публикации: статья из журнала

Год издания: 2011

Идентификатор DOI: 10.1007/s10517-011-1260-9

Ключевые слова: lymphocytes, calcium cations, cisplatin, Ehrlich ascitic carcinoma, calcium ion, reduced nicotinamide adenine dinucleotide phosphate, acidification, animal cell, animal experiment, animal model, article, calcium cell level, cancer staging, cell membrane fluidity, cell pH, controlled study, cytosol, drug effect, Ehrlich ascites tumor, lipid bilayer, lymphocyte function, lymphocyte membrane, lymphocyte structure, mouse, nonhuman, Animals, Antineoplastic Agents, Calcium, Carcinoma, Ehrlich Tumor, Hydrogen-Ion Concentration, Injections, Intraperitoneal, Male, Membrane Fluidity, Mice, Mice, Inbred ICR, NADP, Animalia, Mus

Аннотация: The effects of cisplatin on [Ca(2+)](in), pH(in), NAD(P) H level, and lymphocyte membrane microviscosity were studied in mice with Ehrlich ascitic carcinoma. The level of free [Ca(2+)](in) in lymphocytes from mice with Ehrlich ascitic carcinoma was 4-fold reduced compared to that in intact animals on day 13 of tumor development, whПоказать полностьюile [H(+)](in) level was elevated. Cisplatin caused no changes in the level of free Ca(2+), but reduced cytosol acidification. Lymphocyte membrane fluidity in mice with tumors was increased in the lipid bilayer and in the protein-lipid contact zone and did not depend on cisplatin treatment. The level of NAD(P) H was low in mice with tumors, but increased sharply after cisplatin treatment. It seems that functional activity of lymphocytes decreased at the stage of well-developed tumor, which promoted inhibition of the lymphocyte defense properties. Cisplatin did not modify the structure and functions of lymphocytes and presumably even improved their energy status.

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Выпуск журнала: Vol. 151, Is. 1

Номера страниц: 62-65

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER


  • Zamay T.N. (Siberian Federal University)
  • Kolovskaya O.S. (Siberian Federal University)
  • Zamay G.S. (Siberian Federal University)
  • Borodina N.A. (Siberian Federal University)

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