Тип публикации: статья из журнала
Год издания: 2017
Идентификатор DOI: 10.1007/s10517-017-3868-x
Ключевые слова: experimental tumor metastases in the lungs, leukemia L-1210, radioprotectors, radiotherapy, yeast RNA preparation
Аннотация: We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increaseПоказать полностьюd 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors. © 2017, Springer Science+Business Media, LLC.
Журнал: Bulletin of Experimental Biology and Medicine
Выпуск журнала: Vol. 163, Is. 5
Номера страниц: 639-642
ISSN журнала: 00074888
Издатель: Springer New York LLC