Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/s10517-017-3924-6

Ключевые слова: alkoxyamines, phagocytic activity of peritoneal macrophages, toxicity, transplanted tumor strains, tumor cell lines

Аннотация: Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opПоказать полностьюposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed. © 2017, Springer Science+Business Media, LLC, part of Springer Nature.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 164, Is. 1

Номера страниц: 49-53

ISSN журнала: 00074888

Издатель: Springer New York LLC

• Popova N.A. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Sysoeva G.M. (Institute of Medical Biotechnology, Vektor State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russian Federation)
• Nikolin V.P. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Kaledin V.I. (Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Tretyakov E.V. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Edeeva M.V. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)
• Balakhnin S.M. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)
• Lushnikova E.L. (Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russian Federation)
• Audran G. (Aix Marseille University, Provence, France)
• Mark S. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russian Federation)

• Scopus