Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/s00723-017-0960-3

Аннотация: The renovascular model of arterial hypertension (AH) was induced in Wistar and OXYS strains. The model of AH was verified by magnetic resonance angiography. It was shown that histochrome enhances the vasodilatory effect of selective beta1 blocker, nebivalol, against cerebral and renal arteries using a combined therapy in this modelПоказать полностью. Monotherapy with histochrome had no significant effect on blood pressure. The angioprotective effect of histochrome in the combined therapy was significantly more expressed in hypertensive OXYS rats compared to hypertensive Wistar rats as shown by magnetic resonance imaging (MRI) morphometry. These differences were more observable in the intrarenal part of renal arteries. The degree of regional discirculation of arteries was calculated by the Cerebro-Renal Vascular Index, which confirms the therapeutic advantage of combined therapy with histochrome and nebivalol in the background of AH. Thus, comparative MRI angiography and MRI morphometry of the cerebral and renal arteries in hypertensive Wistar and OXYS strain rats showed that histochrome expands the therapeutic potential of nebivalol due to angioprotective effects in the vascular region of the target organs. © 2017 Springer-Verlag GmbH Austria

Журнал: Applied Magnetic Resonance

Номера страниц: 1-9

ISSN журнала: 09379347

Издатель: Springer-Verlag Wien

• Agafonova I.G. (G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branches of the Russian Academy of Sciences, Vladivostok, Russian Federation)
• Kotelnikov V.N. (Far Eastern Branches of the State Research and Test Institute of Military Medicine of the Ministry Defense of the Russian Federation, Vladivostok, Russian Federation)
• Geltser B.I. (Far Eastern Federal University, Vladivostok, Russian Federation)
• Kolosova N.G. (Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russian Federation)
• Stonik V.A. (G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branches of the Russian Academy of Sciences, Vladivostok, Russian Federation)

• Scopus