Properties and Biocompatibility of Poly-3-Hydroxybutyrate-co-3-Hydroxyvalerate/ Poly-?-Caprolactone Blends

Описание

Перевод названия: Свойства и биосовместимость смесей поли-3-гидроксибутирата-3-гидроксивалерата с поли-?-капролактоном

Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.17516/1997-1389-2015-9-1-63-74

Ключевые слова: poly-3-hydroxybutyrate-co-3-hydroxyvalerate copolymer, poly-?-caprolactone, polymer blends, biopolymers, biocompatibility

Аннотация: Blends consisting of the poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) copolymer and poly?-caprolactone (PCL) were used to prepare polymer ?lms by casting solution technique. The structure and physical-mechanical, and biological properties of the ?lms were examined as in?uenced by the ratios of the blend components. The microsПоказать полностьюtructure of the ?lms was determined by the dominant component: the ?lms had porous surface if the percentage of PHBV was higher than that of PCL and were relatively smooth if the dominant component was PCL. The highest elongation at break (190-368 %) was exhibited by the ?lms prepared from the blends containing 5-25 % PHBV; at 25 % PHBV, local maxima of tensile strength (16 MPa) and Young's modulus (529 MPa) were observed. Biocompatibility of the ?lms prepared from the blends was studied in the culture of NIH 3T3 mouse ?broblast cells. Results of SEM and DAPI staining, determination of the number of attached cells, and MTT assay showed the absence of cytotoxic effects and high cell adhesion and proliferation, which in some cases were higher than on ?lms prepared from pure PHBV and PCL. Thus, PHBV/PCL blends are suitable materials for constructing cell scaffolds for tissue engineering and other reconstructive technologies.

Ссылки на полный текст

Издание

Журнал: Журнал Сибирского федерального университета. Серия: Биология

Выпуск журнала: Т.9, 1

Номера страниц: 63-74

ISSN журнала: 19971389

Место издания: Красноярск

Издатель: Федеральное государственное автономное образовательное учреждение высшего образования Сибирский федеральный университет

Авторы

  • Boyandin Anatoly N. (Siberian Federal University)
  • Nikolaeva Elena D. (Institute of Biophysics of SB RAS)
  • Sukovatiy Aleksey G. (Institute of Biophysics of SB RAS)

Вхождение в базы данных