Polyhydroxyalkanoates (PHA) for therapeutic applications


Тип публикации: статья из журнала

Год издания: 2018

Идентификатор DOI: 10.1016/j.msec.2017.12.035

Ключевые слова: Biomedicine, Drug delivery, Implants, PHA, Therapeutics, Tissue engineering

Аннотация: As intracellular carbon and energy storage materials, polyhydroxyalkanoates (PHA) are a diverse biopolyesters synthesized by many bacteria. PHA have been produced in large quantity for various application research including medical implants for approximately 30. years. Many studies demonstrated that PHA are promising implant materiПоказать полностьюals due to their diverse and ascendant mechanical, biodegradable and tissue compatible properties. Importantly, common PHA biodegradation products including oligomers and monomers are also not toxic to the cells and tissues. Pharmaceutical applications of some PHA degradation products also have been reported. So far, no study has been reported to have any carcinogenesis result induced by any PHA or their biodegradation products. All results suggest that PHA could be developed into various bio-implant products. © 2018 Elsevier B.V.

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Журнал: Materials Science and Engineering C

Издатель: Elsevier Ltd


  • Zhang J. (Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China)
  • Shishatskaya E.I. (Siberian Federal University, 660041 Krasnoyarsk, Russia)
  • Volova T.G. (Institute of Biophysics of Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, 660036, Russia)
  • da Silva L.F. (University of Sao Paulo, Institute of Ciencias Biomedicine, Dept Microbiology, BR-05509900 Sao Paulo, Brazil)
  • Chen G.-Q. (MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China)

Вхождение в базы данных

  • Scopus (цитирований 1)