Polyhydroxyalkanoates (PHA) for therapeutic applications

Описание

Тип публикации: статья из журнала

Год издания: 2018

Идентификатор DOI: 10.1016/j.msec.2017.12.035

Ключевые слова: Biomedicine, Drug delivery, Implants, PHA, Therapeutics, Tissue engineering

Аннотация: As intracellular carbon and energy storage materials, polyhydroxyalkanoates (PHA) are a diverse biopolyesters synthesized by many bacteria. PHA have been produced in large quantity for various application research including medical implants for approximately 30. years. Many studies demonstrated that PHA are promising implant materiПоказать полностьюals due to their diverse and ascendant mechanical, biodegradable and tissue compatible properties. Importantly, common PHA biodegradation products including oligomers and monomers are also not toxic to the cells and tissues. Pharmaceutical applications of some PHA degradation products also have been reported. So far, no study has been reported to have any carcinogenesis result induced by any PHA or their biodegradation products. All results suggest that PHA could be developed into various bio-implant products. © 2018 Elsevier B.V.

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Издание

Журнал: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

Выпуск журнала: Vol. 86

Номера страниц: 144-150

Место издания: AMSTERDAM

Издатель: ELSEVIER SCIENCE BV

Авторы

  • Zhang Junyu (Nanchang Univ, Inst Life Sci, Lab Fear & Anxiety Disorders, Nanchang 330031, Jiangxi, Peoples R China)
  • Shishatskaya Ekaterina I. (Siberian Fed Univ, Krasnoyarsk 660041, Russia)
  • Volova Tatiana G. (Russian Acad Sci, Inst Biophys, Siberian Branch, Krasnoyarsk 660036, Russia)
  • da Silva Luiziana Ferreira (Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05509900 Sao Paulo, Brazil)
  • Chen Guo-Qiang (Tsinghua Univ, Sch Life Sci, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China)

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