Тип публикации: статья из журнала
Год издания: 2017
Идентификатор DOI: 10.15789/1563-0625-2017-5-577-584
Ключевые слова: Anti-idiotypic antibodies, Antibodies, Breast cancer, Carcinogenesis, Estradiol, Progesterone
Аннотация: Antibodies against sex steroid hormones are known to modulate their serum concentration and inhibit experimental breast cancer (BC). Hence, these effects could be changed by according anti-idiotypic antibodies. However, relationships between antibodies and anti-idiotypic antibodies and BC in women are still poorly studied. The aim Показать полностьюof this study was to identify possible associations between occurrence of antibodies against estradiol and progesterone (IgG-Es1and IgG-Pg1) and according antiidiotypic antibodies (IgG-Es2 and IgG-Pg2), and postmenopausal BC. Eighty-nine healthy women and 273 BC patients were examined. A non-competitive solid phase immunoassay for IgG-Es1 and IgG-Pg1 was performed using estradiol and progesterone conjugates with bovin serum albumin as antigens. Monoclonal antibodies against Es and Pg as antigens have been used for noncompetitive solid phase immunoassay of IgG-Es2 and IgG-Pg2. Results: absence of both IgG-Es1 and IgG-Pg1 was revealed in 53.9% of healthy donors and 41.0% of BC patients (p = 0.04; OR = 0.6). Presence of IgG-Es1 without IgG-Pg1, or IgG-Pg1 without IgG-Es1was detected for, respectively, 15.7% and 20.2% of healthy women, and in 10.3% and 7.7% of BC patients (p > 0.05). Simultaneous increase of both IgG-Es1 and IgG-Pg1 was revealed in 10.1% of healthy donors and in 41.0% of BC patients (p
Журнал: Medical Immunology (Russia)
Выпуск журнала: Vol. 19, Is. 5
Номера страниц: 577-584
ISSN журнала: 15630625
Издатель: Russian Association of Allergologists and Clinical Immunologists, St. Petersburg Regional Branch (SPb RAACI)