Antibodies and anti-antibodies to steroid hormones, and breast cancer risk : научное издание

Описание

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.15789/1563-0625-2017-5-577-584

Ключевые слова: Anti-idiotypic antibodies, Antibodies, Breast cancer, Carcinogenesis, Estradiol, Progesterone

Аннотация: Antibodies against sex steroid hormones are known to modulate their serum concentration and inhibit experimental breast cancer (BC). Hence, these effects could be changed by according anti-idiotypic antibodies. However, relationships between antibodies and anti-idiotypic antibodies and BC in women are still poorly studied. The aim Показать полностьюof this study was to identify possible associations between occurrence of antibodies against estradiol and progesterone (IgG-Es1and IgG-Pg1) and according antiidiotypic antibodies (IgG-Es2 and IgG-Pg2), and postmenopausal BC. Eighty-nine healthy women and 273 BC patients were examined. A non-competitive solid phase immunoassay for IgG-Es1 and IgG-Pg1 was performed using estradiol and progesterone conjugates with bovin serum albumin as antigens. Monoclonal antibodies against Es and Pg as antigens have been used for noncompetitive solid phase immunoassay of IgG-Es2 and IgG-Pg2. Results: absence of both IgG-Es1 and IgG-Pg1 was revealed in 53.9% of healthy donors and 41.0% of BC patients (p = 0.04; OR = 0.6). Presence of IgG-Es1 without IgG-Pg1, or IgG-Pg1 without IgG-Es1was detected for, respectively, 15.7% and 20.2% of healthy women, and in 10.3% and 7.7% of BC patients (p > 0.05). Simultaneous increase of both IgG-Es1 and IgG-Pg1 was revealed in 10.1% of healthy donors and in 41.0% of BC patients (p

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Издание

Журнал: Medical Immunology (Russia)

Выпуск журнала: Vol. 19, Is. 5

Номера страниц: 577-584

ISSN журнала: 15630625

Издатель: Russian Association of Allergologists and Clinical Immunologists, St. Petersburg Regional Branch (SPb RAACI)

Персоны

  • Glushkov A.N. (Laboratory of Immunochemistry, Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Leningradsky ave, 10., Kemerovo, Russian Federation, Department of Genetics, Faculty of Biology, Kemerovo State University, Kemerovo, Russian Federation)
  • Polenok E.G. (Laboratory of Immunochemistry, Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Leningradsky ave, 10., Kemerovo, Russian Federation)
  • Kostyanko M.V. (Department of Organic Chemistry, Faculty of Chemistry, Kemerovo State University, Kemerovo, Russian Federation)
  • Antonov A.V. (Mammology Department, Regional Dispensary for Clinical Oncology, Kemerovo, Russian Federation)
  • Verzhbitskaya N.E. (Department of Pathology, Regional Pathologoanatomical Bureau, Kemerovo, Russian Federation)
  • Vafin I.A. (Regional Blood Center, Kemerovo, Russian Federation)
  • Ragozhina S.E. (Regional Blood Center, Kemerovo, Russian Federation)

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