Regulation of contractile responses of vascular smooth muscle cells under conditions of hypoxia-reoxygenation

Описание

Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1007/s10517-016-3574-0

Ключевые слова: hypoxia, K+-ATPase, Na+, rat aorta, Reoxygenation, smooth muscle cells

Аннотация: We analyzed the effects of hypoxia and reoxygenation on changes in contractile activity in rat aortic smooth muscles. Both hypoxia and reoxygenation induced relaxation of smooth muscle cells precontracted with high-potassium Krebs solution (30 mM KCl) or α1-adrenoceptor agonist phenylephrine. Vasodilation resulted from enhancement Показать полностьюof potassium permeability of smooth muscle cell membranes caused by activation of voltage-gated potassium channels (triggered by both precontracting agents) or by opening of ATP-sensitive potassium channels (phenylephrine). In isolated smooth muscle cells, both hypoxia and inhibition of Na+, K+-ATPase with ouabain led to depletion of intracellular store of macroergic substances, reduced potassium concentration, and elevated the content of sodium ions.

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Издание

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Т.162, 2

Номера страниц: 195-198

ISSN журнала: 00074888

Место издания: Москва

Издатель: Springer New York Consultants Bureau

Авторы

  • Gusakova S.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
  • Birulina Y.G. (Siberian State Medical University,Ministry of Health of the Russian Federation)
  • Smagliy L.V. (National Research Tomsk Polytechnic University)
  • Kovalev I.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
  • Petrova I.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
  • Nosarev A.V. (National Research Tomsk Polytechnic University)
  • Orlov S.N. (National Research Tomsk Polytechnic University)

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