Secret life of tiny blood vessels: Lactate, scaffold and beyond

Описание

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/978-3-319-56148-6_53

Ключевые слова: Angiogenesis in vitro, Brain microvessel endothelial cells, form factor, fractal dimension, Gelatin scaffold

Аннотация: We studied the model of cerebral angiogenesis in vitro using lactate-releasing gelatin bioscaffolds and primary culture of brain endothelial cells. We found that development of microvessels from actively proliferating rat brain microvessels endothelial cells was greatly modified by the presence of lactate at the surface of the scafПоказать полностьюfold with different lactate-releasing ability. Fractal dimension of newly-established vessel loops allows precise characterizing the local microenvironment supporting cell growth on various types of gelatin scaffolds.

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Издание

Журнал: Lecture Notes in Computer Science

Выпуск журнала: Т.10208 LNCS, №

Номера страниц: 591-601

ISSN журнала: 03029743

Издатель: Springer-Verlag GmbH

Авторы

  • Salmin V. (Institute of Computational Modelling of SB RAS)
  • Morgun A. (Institute of Computational Modelling of SB RAS)
  • Khilazheva E. (Institute of Computational Modelling of SB RAS)
  • Pisareva N. (Institute of Computational Modelling of SB RAS)
  • Boitsova E. (Institute of Computational Modelling of SB RAS)
  • Lavrentiev P. (Institute of Computational Modelling of SB RAS)
  • Sadovsky M. (Institute of Computational Modelling of SB RAS)
  • Salmina A. (Institute of Computational Modelling of SB RAS)

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