Ultrafine Betulin Formulation with Biocompatible Carriers Exhibiting Improved Dissolution Rate

Описание

Тип публикации: статья из журнала

Год издания: 2015

Ключевые слова: Betulin, Solubilization, Polyethylene glycol, Glycine, Freeze-drying, Ball-milling

Аннотация: The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and beta-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly hiПоказать полностьюgher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.

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Издание

Журнал: NATURAL PRODUCT COMMUNICATIONS

Выпуск журнала: Vol. 10, Is. 8

Номера страниц: 1345-1347

ISSN журнала: 1934578X

Место издания: WESTERVILLE

Издатель: NATURAL PRODUCTS INC

Авторы

  • Myz S.A. (Institute of Solid State Chemistry and Mechanochemistry SB RAS)
  • Shakhtshneider T.P. (Institute of Solid State Chemistry and Mechanochemistry SB RAS)
  • Bogdanova E.G. (Nikolaev Institute of Inorganic Chemistry SB RAS)
  • Boldyreva E.V. (Institute of Solid State Chemistry and Mechanochemistry SB RAS)
  • Boldyrev V.V. (Institute of Solid State Chemistry and Mechanochemistry SB RAS)
  • Mikhailenko M.A. (Institute of Solid State Chemistry and Mechanochemistry SB RAS)
  • Ogienko A.G. (Mendeleev College of Chemistry and Technology)
  • Ogienko A.A. (Institute of Cytology and Genetics SB RAS)
  • Kuznetsova S.A. (Siberian Federal University)

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