Noninvasive Microsurgery Using Aptamer-Functionalized Magnetic Microdisks for Tumor Cell Eradication

Описание

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1089/nat.2016.0634

Ключевые слова: aptamer, magnetic microdisks, magnetodynamic therapy, tumor eradication

Аннотация: Magnetomechanical cell disruption using nano- and microsized structures is a promising biomedical technology used for noninvasive elimination of diseased cells. It applies alternating magnetic field (AMF) for ferromagnetic microdisks making them oscillate and causing cell membrane disruption with cell death followed by apoptosis. IПоказать полностьюn this study, we functionalized the magnetic microdisks with cell-binding DNA aptamers and guided the microdisks to recognize cancerous cells in a mouse tumor in vivo. Only 10 min of the treatment with a 100 Hz AMF was enough to eliminate cancer cells from a malignant tumor. Our results demonstrate a good perspective of using aptamer-modified magnetic microdisks for noninvasive microsurgery for tumors. © Mary Ann Liebert, Inc. 2017.

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Издание

Журнал: Nucleic Acid Therapeutics

Выпуск журнала: Vol. 27, Is. 2

Номера страниц: 105-114

ISSN журнала: 21593337

Авторы

  • Zamay Tatiana N. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia; Siberian Fed Univ, Krasnoyarsk, Russia)
  • Zamay Galina S. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Belyanina Irina V. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia; Siberian Fed Univ, Krasnoyarsk, Russia)
  • Zamay Sergey S. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Denisenko Valery V. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia; Russian Acad Sci, Siberian Branch, Inst Computat Modeling, Krasnoyarsk, Russia)
  • Kolovskaya Olga S. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Ivanchenko Tatiana I. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Grigorieva Valentina L. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia; Siberian Fed Univ, Krasnoyarsk, Russia)
  • Garanzha Irina V. (Siberian Fed Univ, Krasnoyarsk, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Veprintsev Dmitry V. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Glazyrin Yury E. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia)
  • Shabanov Alexandr V. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Prinz Viktor Y. (Russian Acad Sci, Siberian Branch, Inst Semicond Phys, Novosibirsk, Russia)
  • Seleznev Vladimir A. (Russian Acad Sci, Siberian Branch, Inst Semicond Phys, Novosibirsk, Russia)
  • Sokolov Alexey E. (Russian Acad Sci, Siberian Branch, Inst Phys, Krasnoyarsk, Russia)
  • Prokopenko Vladimir S. (Krasnoyarsk State Pedag Univ, Krasnoyarsk, Russia)
  • Kim Petr D. (Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)
  • Gargaun Ana (Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON, Canada)
  • Berezovski Maxim V. (Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON, Canada)
  • Zamay Anna S. (Krasnoyarsk State Med Univ, Lab Biomol & Med Technol, 1,P Zheleznyaka, Krasnoyarsk 660022, Russia; Russian Acad Sci, Siberian Branch, Krasnoyarsk Res Ctr, Krasnoyarsk, Russia)

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