Тип публикации: статья из журнала
Год издания: 2016
Идентификатор DOI: 10.1134/S1990750816030161
Ключевые слова: oxidative stress, cell redox status, protein oxidative modification, breast epithelial cells
Аннотация: The effects of N-ethylmaleimide (NEM) and 1,4-dithioerythritol (DTE) on the level of oxidative modification of proteins, the state of glutathione and thioredoxin systems and the cellular redox status have been investigated in HBL-100 cells (breast epithelial cells). Breast epithelial cells cultivated in the presence of NEM were chaПоказать полностьюracterized by the decreased redox status, increased glutathione reductase activity, and increased concentrations of products of irreversible oxidative modification of proteins and amino acids. Cell cultivation in the presence of DTE shifted the redox status towards reduction processes and increased reversible protein modification by glutathionylation. The proposed model of intracellular redox modulation may be used in the development of new therapeutic approaches to treat diseases accompanied by impaired redox homeostasis (e.g. oncologic, inflammatory, cardiovascular and neurodegenerative disease).
Журнал: BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
Выпуск журнала: Vol. 10, Is. 3
Номера страниц: 235-239
ISSN журнала: 19907508
Место издания: MOSCOW
Издатель: MAIK NAUKA-INTERPERIODICA