Optimization of photothermal methods for laser hyperthermia of malignant cells using bioconjugates of gold nanoparticles


Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1134/S1061933X16040050

Ключевые слова: Biomolecules, Cell membranes, Cells, Continuous wave lasers, Cytology, Fiber optic sensors, Gold, Laser radiation, Metal nanoparticles, Nanoparticles, Oligonucleotides, Bioconjugates, Cell surfaces, Cellular membranes, DNA aptamers, Gold Nanoparticles, Malignant cells, Photothermal methods, Pulsed lasers

Аннотация: Selective action of laser radiation on membranes of malignant cells has been studied in different regimes using conjugates of gold nanoparticles with oligonucleotides by the example of DNA aptamers. Under the conditions of a contact between a bioconjugate and a cell surface and the development of substantial and rapidly relaxing teПоказать полностьюmperature gradients near a nanoparticle, the membranes of malignant cells alone are efficiently damaged due to the local hyperthermia of a cellular membrane. It has been shown that employment of pulsed instead of continuous wave laser radiation provides the localization of the damaging action, which does not involve healthy cells.

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Выпуск журнала: Vol. 78, Is. 4

Номера страниц: 435-442

ISSN журнала: 1061933X

Место издания: NEW YORK



  • Gerasimov V.S. (Siberian Federal University)
  • Ershov A.E. (Kirenskii Institute of Physics,Siberian Branch,Russian Academy of Sciences)
  • Karpov S.V. (Reshetnev State Siberian State Aerospace University)
  • Polyutov S.P. (Siberian Federal University)
  • Semina P.N. (Kirenskii Institute of Physics,Siberian Branch,Russian Academy of Sciences)

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