Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.2174/1570180814666161121112417

Ключевые слова: Antidepressant, BDNF, depression, serotonin, STEP, TC-2153

Аннотация: Background: Depressive disorders are among four leading causes of burden among the most disabling medical illnesses and antidepressant drugs (AD) occupying leading positions in the worldwide pharmaceutical market. However, typical AD show prolonged delay, refractory and adverse side effects. Methodology: The review analyzes experimПоказать полностьюental data and theoretical models of possible antidepressant effect of benzopentathiepine, 8-(trifluoromethyl)-1,2,3,4,5 - benzopentathiepin-6- amine hydrochloride (TC-2153). The antidepressant effect of TC-2153 is based on its ability to inhibit striatal enriched protein tyrosine phosphatase (STEP)- an enzyme that plays a key role in the intraneuronal transduction of signals from receptors of classic neurotransmitters and the brain derived neurotrophic factor (BDNF). The mechanism underlying antidepressant effect of TC-2153 includes increase in production as well as intracellular effect of BDNF on neuronal survival and neurogenesis. Results and Conclusion: There is no visible mechanisms of delay, refractory and adverse side effects of TC-2153. Thus, TC-2153 is a promising drug of new generation of atypical AD. © 2017 Bentham Science Publishers.

Журнал: Letters in Drug Design and Discovery

Выпуск журнала: Vol. 14, Is. 8

Номера страниц: 974-984

ISSN журнала: 15701808

Издатель: Bentham Science Publishers B.V.

• Kulikova E.A. (Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentjev Avenue, 10, Novosibirsk, Russian Federation)
• Volcho K.P. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branchof Russian Academy of Sciences, Lavrentjev Avenue, Novosibirsk, Russian Federation, Novosibirsk State University, Pirogova 2, Novosibirsk, Russian Federation)
• Salakhutdinov N.F. (N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branchof Russian Academy of Sciences, Lavrentjev Avenue, Novosibirsk, Russian Federation, Novosibirsk State University, Pirogova 2, Novosibirsk, Russian Federation)
• Kulikov A.V. (Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentjev Avenue, 10, Novosibirsk, Russian Federation, Novosibirsk State University, Pirogova 2, Novosibirsk, Russian Federation)

• Scopus