A complex of ceftriaxone with Pb(II): synthesis, characterization, and antibacterial activity study

Описание

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1080/00958972.2014.938065

Ключевые слова: Ceftriaxone lead(II) complex, DFT, IR spectroscopy, TGA, Antibacterial screening, DFT; IR spectroscopy

Аннотация: A Pb(II) complex with ceftriaxone (H2Ceftria) antibiotic was synthesized by reaction of ceftriaxone disodium salt (hemi) heptahydrate with lead nitrate in water-ethanol medium. The complex was characterized on the basis of complexometric titration, spectrophotometric and thermogravimetric analyses, capillary electrophoresis, IR, RaПоказать полностьюman and UV-vis spectroscopies, and density functional theory calculations. Pb(II) is five-coordinate with distorted square pyramidal geometry. The coordination of Ceftria(2-) to Pb(II) occurs through N and O of the triazine, lactam carbonyl, carboxylate, and amine groups. The antibacterial activity study showed that Klebsiella pneumoniae is resistant to [Pb(Ceftria)]center dot 3H(2)O. The antibacterial activity of [Pb(Ceftria)]center dot 3H(2)O against Staphylococcus aureus is reduced compared with ceftriaxone. In contrast, the antibacterial activity of [Pb(Ceftria)]center dot 3H(2)O against Escherichia coli is 28% higher than that of ceftriaxone antibiotic.

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Издание

Журнал: JOURNAL OF COORDINATION CHEMISTRY

Выпуск журнала: Vol. 67, Is. 16

Номера страниц: 2783-2794

ISSN журнала: 00958972

Место издания: ABINGDON

Издатель: TAYLOR & FRANCIS LTD

Персоны

  • Lykhin Aleksandr O. (Siberian Fed Univ, Dept Chem, Krasnoyarsk, Russia; Siberian State Aerosp Univ, Informat Sci & Telecommun Inst, Krasnoyarsk, Russia)
  • Novikova Galina V. (Siberian Fed Univ, Dept Chem, Krasnoyarsk, Russia)
  • Kuzubov Alexander A. (Siberian Fed Univ, Dept Chem, Krasnoyarsk, Russia; Russian Acad Sci, LV Kirensky Inst Phys, Siberian Branch, Krasnoyarsk, Russia; Siberian State Technol Univ, Dept Phys, Krasnoyarsk, Russia)
  • Staloverova Natalia A. (Siberian Fed Univ, Dept Chem, Krasnoyarsk, Russia)
  • Sarmatova Natalia I. (Siberian Fed Univ, Dept Chem, Krasnoyarsk, Russia)
  • Varganov Sergey A. (Univ Nevada, Dept Chem, Reno, NV 89557 USA)
  • Krasnov Pavel O. (Siberian State Technol Univ, Dept Phys, Krasnoyarsk, Russia)