AsLn2, a luciferin-related modified tripeptide from the bioluminescent earthworm Fridericia heliota

Описание

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1016/j.tetlet.2013.11.061

Ключевые слова: Bioluminescence, Fridericia heliota, Luciferin, Modified peptide, AsLn2 tripeptide, n (omega)acylated lysine, tripeptide, tyrosine, unclassified drug, asln2 peptide, lysine derivative, n(omega) acylated lysine, peptides and proteins, protein compX, article, biosynthesis, chemical structure, chromatography, controlled study, earthworm, heteronuclear multiple bond correlation, heteronuclear single quantum coherence, mass spectrometry, nonhuman, nuclear magnetic resonance spectroscopy, protein modification, proton nuclear magnetic resonance, ultraviolet radiation, protein isolation, protein structure, Enchytraeidae

Аннотация: AsLn2, an unusual modified peptide, was isolated from the bioluminescent earthworm Fridericia heliota (Enchytraeidae). Its structure, elucidated by NMR and mass spectrometry, includes residues of tyrosine, CompX (a novel tyrosine modification product, reported in the accompanying paper), and N(omega)-acylated lysine. ChromatographyПоказать полностью, UV, and H-1 NMR data imply a close structural similarity of AsLn2 with F. heliota luciferin. AsLn2 appears to be an intermediate or by-product in F. heliota luciferin biosynthesis. (C) 2013 Elsevier Ltd. All rights reserved.

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Издание

Журнал: TETRAHEDRON LETTERS

Выпуск журнала: Vol. 55, Is. 2

Номера страниц: 463-465

ISSN журнала: 00404039

Место издания: OXFORD

Издатель: PERGAMON-ELSEVIER SCIENCE LTD

Персоны

  • Petushkov Valentin N. (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Lab Bioluminescent Biotechnol, Krasnoyarsk 660041, Russia; Russian Acad Sci, Inst Biophys, Lab Photobiol, Siberian Branch, Krasnoyarsk 660036, Russia)
  • Dubinnyi Maxim A. (Russian Acad Sci, Inst Bioorgan Chem, Moscow 117997, Russia)
  • Rodionova Natalja S. (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Lab Bioluminescent Biotechnol, Krasnoyarsk 660041, Russia; Russian Acad Sci, Inst Biophys, Lab Photobiol, Siberian Branch, Krasnoyarsk 660036, Russia)
  • Nadezhdin Kirill D. (Russian Acad Sci, Inst Bioorgan Chem, Moscow 117997, Russia)
  • Marques Simone M. (Univ Porto, Fac Sci, Dept Chem & Biochem, Chem Res Ctr Univ Porto CIQUP, P-4169007 Oporto, Portugal)
  • Esteves da Silva Joaquim C. G. (Univ Porto, Fac Sci, Dept Chem & Biochem, Chem Res Ctr Univ Porto CIQUP, P-4169007 Oporto, Portugal)
  • Shimomura Osamu (Siberian Fed Univ, Inst Fundamental Biol & Biotechnol, Lab Bioluminescent Biotechnol, Krasnoyarsk 660041, Russia)
  • Yampolsky Ilia V. (Russian Acad Sci, Inst Bioorgan Chem, Moscow 117997, Russia)