Informational Way to Protein Alphabet: Entropic Classification of Amino Acids

Описание

Тип публикации: доклад, тезисы доклада, статья из сборника материалов конференций

Конференция: XV Всероссийский семинар "Нейроинформатика, её приложения и анализ данных"; Красноярск; Красноярск

Год издания: 2007

Аннотация: What are proteins made from, as the working parts of the living cells protein machines? To answer this question, we need a technology to disassemble proteins onto elementary func-tional details and to prepare lumped description of such details. This lumped description might have a multiple material realization (in amino acids). OurПоказать полностьюhypothesis is that informational approach to this problem is possible. We propose a way of hierarchical classification that makes the primary structure of protein maximally non-random. The first steps of the suggested research program are realized: the method and the analysis of optimal informational protein binary alphabet. The general method is used to answer several specific questions, for example: (i) Is there a syntactic difference between Globular and Membrane proteins? (ii) Are proteins random sequences of amino acids (a long discussion)? For these questions, the answers are as follows: (i) There exists significant syntactic difference between Globular and Membrane proteins, and this difference is described; (ii) Amino acid sequences in proteins are definitely not random.

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Издание

Номера страниц: 3-15

Издатель: Российский фонд фундаментальных исследований

Авторы

  • Gorban A.N. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science)
  • Kudryashev M. (Krasnoyarsk State University??)
  • Popova T.G. (Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science)

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