Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1007/s10517-017-3700-7

Ключевые слова: 16S rRNA sequencing, Gut microbiota, Parkinson’s diseasealpha synuclein, 154040-18-3

Аннотация: Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, PrevotellПоказать полностьюa, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of a-synuclein and generation of Lewy bodies. © 2017 Springer Science+Business Media New York.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 162, Is. 6

Номера страниц: 734-737

ISSN журнала: 00074888

Издатель: Springer New York LLC

• Petrov V.A. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Saltykova I.V. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Zhukova I.A. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Alifirova V.M. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Zhukova N.G. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Dorofeeva Y.B. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Tyakht A.V. (Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation)
• Kovarsky B.A. (Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation)
• Alekseev D.G. (Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation)
• Kostryukova E.S. (Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation)
• Mironova Y.S. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Izhboldina O.P. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Nikitina M.A. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Perevozchikova T.V. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Fait E.A. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation)
• Babenko V.V. (Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation)
• Vakhitova M.T. (Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation)
• Govorun V.M. (Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation)
• Sazonov A.E. (Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation, M. V. Lomonosov Moscow State University, Moscow, Russian Federation)

• Scopus