Тип публикации: статья из журнала

Год издания: 2007

Идентификатор DOI: 10.1007/s10517-007-0220-x

Ключевые слова: Cytokinegene polymorphism, Cytokines, Hepatitis B and C viruses, adenine, cytosine, guanine, interleukin 10, interleukin 2, interleukin 4, thymine, adult, article, Caucasian, controlled study, cytokine production, disease course, female, genetic association, genetic polymorphism, genetic variability, genotype, hepatitis B, Hepatitis B virus, hepatitis C, Hepatitis C virus, human, human cell, immunopathogenesis, immunoregulation, major clinical study, male, persistent virus infection, promoter region, Th2 cell, virus immunity, virus pathogenesis, Adolescent, Blood Donors, Hepatitis B, Chronic, Hepatitis C, Chronic, Humans, Interleukin-10, Interleukin-2, Interleukin-4, Middle Aged

Аннотация: Immunopathogenesis of chronic viral hepatitides was studied by modern immunological, molecular, genetic methods. We revealed an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes (primarily of the Th2 type). The risk of progression and chronic course of viral hepatitides in Caucasian population was Показать полностьюassociated with alleles of promoter regions -330G and -592A in the IL-2 and IL-10 genes, respectively, as well as with the T/T genotype of the polymorphic region C590T in the IL-4 gene. The C/C genotype of the IL-10 gene promoter region C592A was shown to be a factor determining resistance to long-term persistence of hepatitis B and C viruses. © Springer Science+Business Media, Inc. 2007.

Журнал: Bulletin of Experimental Biology and Medicine

Выпуск журнала: Vol. 143, Is. 6

Номера страниц: 706-712

• Naslednikova I.O. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of)
• Konenkov V.I. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of Med)
• Ryazantseva N.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of )
• Novitskii V.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of Me)
• Tkachenko S.B. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of Me)
• Zima A.P. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of Medical)
• Avdoshina V.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of Me)
• Beloborodova E.I. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of)
• Beloborodova E.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of)
• Dortman V.V. (Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russian Federation, Institute of Experimental and Clinical Lymphology, Siberian Division, Russian Academy of Medi)

• Scopus