The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma

Описание

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1134/S1607672917040081

Аннотация: In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acidПоказать полностьюcycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures.

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Издание

Журнал: Doklady Biochemistry and Biophysics

Выпуск журнала: Т.475, 1

Номера страниц: 277-279

ISSN журнала: 16076729

Место издания: Москва

Издатель: Pleiades Publishing, Ltd. (Плеадес Паблишинг, Лтд)

Авторы

  • Inzhevatkin E.V. (Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS)
  • Savchenko A.A. (Research Institute for Medical Problems in the North Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”)

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