Blood-brain barrier-supported neurogenesis in healthy and diseased brain

Описание

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1515/revneuro-2016-0071

Ключевые слова: adult neurogenesis, angiogenesis, blood-brain barrier, neurogenic niche

Аннотация: Adult neurogenesis is one of the most important mechanisms contributing to brain development, learning, and memory. Alterations in neurogenesis underlie a wide spectrum of brain diseases. Neurogenesis takes place in highly specialized neurogenic niches. The concept of neurogenic niches is becoming widely accepted due to growing eviПоказать полностьюdence of the important role of the microenvironment established in the close vicinity to stem cells in order to provide adequate control of cell proliferation, differentiation, and apoptosis. Neurogenic niches represent the platform for tight integration of neurogenesis and angiogenesis supported by specific properties of cerebral microvessel endothelial cells contributing to establishment of partially compromised blood-brain barrier (BBB) for the adjustment of local conditions to the current metabolic needs of stem and progenitor cells. Here, we review up-to-date data on microvascular dynamics in activity-dependent neurogenesis, specific properties of BBB in neurogenic niches, endothelial-driven mechanisms of clonogenic activity, and future perspectives for reconstructing the neurogenic niches in vitro.

Ссылки на полный текст

Издание

Журнал: Reviews in the Neurosciences

Выпуск журнала: Т.28, 4

Номера страниц: 397-415

ISSN журнала: 03341763

Издатель: Freund Publishing House Ltd.

Авторы

  • Pozhilenkova E.A. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University Named after Prof. Voino-Yasenetsky)
  • Lopatina O.L. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University Named after Prof. Voino-Yasenetsky)
  • Komleva Y.K. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University Named after Prof. Voino-Yasenetsky)
  • Salmin V.V. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University Named after Prof. Voino-Yasenetsky)
  • Salmina A.B. (Research Institute of Molecular Medicine and Pathobiochemistry,Krasnoyarsk State Medical University Named after Prof. Voino-Yasenetsky)

Вхождение в базы данных

  • РИНЦ (eLIBRARY.RU) (цитирований 5)
  • Ядро РИНЦ (eLIBRARY.RU)
  • Web of Science Core Collection
  • Scopus