The Use of Polymeric Microcarriers Loaded with Anti-Inflammatory Substances in the Therapy of Experimental Skin Wounds

Описание

Тип публикации: статья из журнала

Год издания: 2014

Идентификатор DOI: 10.1007/s10517-014-2624-8

Ключевые слова: degradable polymers, poly-3-hydroxybutyrate, systems of controlled drug delivery, polymeric microparticles, experimental skin lesions, degradable polymers, experimental skin lesions, poly-3-hydroxybutyrate, polymeric microparticles, systems of controlled drug delivery, dexamethasone, diclofenac, polyester, polyhydroxyalkanoic acid, polymer, antiinflammatory agent, drug carrier, polymer, acanthosis, animal experiment, animal tissue, antiinflammatory activity, Article, burn, controlled study, mouse, nonhuman, sebaceous gland, skin biopsy, skin injury, skin necrosis, therapy, wound healing, animal, Bagg albino mouse, chemistry, injuries, skin, Wounds and Injuries, Animals, Anti-Inflammatory Agents, Drug Carriers, Mice, Mice, Inbred BALB C, Polymers, Skin, Wounds and Injuries

Аннотация: We studied the effects of anti-inflammatory substances incorporated in polymeric microparticles made of degradable natural polyhydroxyalkanoate polyesters on experimental skin wounds caused by chemical burns in laboratory animals. Treatment with encapsulated forms of anti-inflammatory substances (applied in gel) accelerated wound hПоказать полностьюealing in comparison with routine therapy (estimated by area of burn wound, wound healing activity, number of acanthotic cells, and number of hair and sebaceous follicles). The results showed the perspectives of usage of developed form of substances (degradable polymeric microparticles) for treatment of skin defects.

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Издание

Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Выпуск журнала: Vol. 157, Is. 5

Номера страниц: 597-602

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER

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