Тип публикации: статья из журнала
Год издания: 2017
Идентификатор DOI: 10.1007/s10517-017-3801-3
Ключевые слова: ascitic tumor, liposomes, metastases, platinum compoundsphosphatidylcholine, 55128-59-1, 8002-43-5
Аннотация: Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operableПоказать полностьюprimary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment). © 2017, Springer Science+Business Media, LLC.
Журнал: Bulletin of Experimental Biology and Medicine
Выпуск журнала: Vol. 163, Is. 3
Номера страниц: 349-351
ISSN журнала: 00074888
Издатель: Springer New York LLC