Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1021/acs.inorgchem.7b02212

Аннотация: Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such as blue-light photodynamic therapy. However, their singlet oxygen generation ability as well as biological properties have been studied only superficiПоказать полностьюally. Herein we investigate in detail the singlet oxygen photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, cellular localization and in vitro photoinduced oxidative stress, and photodynamic cytotoxicity of the series of octahedral rhenium cluster complexes [{Re6Q8}(CN)6]4-, where Q = S, Se, Te. Our results demonstrate that the selenium-containing complex possesses optimal properties in terms of absorption and singlet oxygen productivity. These features coupled with the cellular internalization and low dark toxicity lead to the first photoinduced cytotoxic effect observed for a molecular [{M6Q8}L6] complex, making it a promising object for further study in terms of blue-light PDT. © 2017 American Chemical Society.

Журнал: Inorganic Chemistry

Выпуск журнала: Vol. 56, Is. 21

Номера страниц: 13491-13499

ISSN журнала: 00201669

Издатель: American Chemical Society

• Solovieva A.O. (Research Institute of Experimental and Clinical Medicine, 2 Timakova st., Novosibirsk, Russian Federation, Research Institute of Clinical and Experimental Lymphology, Branch of the ICG SB RAS, 2 Timakova st., Novosibirsk, Russian Federation)
• Kirakci K. (Institute of Inorganic Chemistry, Czech Academy of Sciences V.v.i., Husinec-Řež 1001, Řež, United States)
• Ivanov A.A. (Research Institute of Experimental and Clinical Medicine, 2 Timakova st., Novosibirsk, Russian Federation, Nikolaev Institute of Inorganic Chemistry SB RAS, 3, Acad. Lavrentiev Ave., Novosibirsk, Russian Federation)
• Kubát P. (J. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences V.v.i., Dolejškova 3, Praha 8, Czech Republic)
• Pozmogova T.N. (Research Institute of Clinical and Experimental Lymphology, Branch of the ICG SB RAS, 2 Timakova st., Novosibirsk, Russian Federation, Novosibirsk State University, 2 Pirogova Str., Novosibirsk, Russian Federation)
• Miroshnichenko S.M. (Research Institute of Clinical and Experimental Lymphology, Branch of the ICG SB RAS, 2 Timakova st., Novosibirsk, Russian Federation)
• Vorontsova E.V. (Institute of Molecular Biology and Biophysics, 2/12 Timakova st., Novosibirsk, Russian Federation)
• Chechushkov A.V. (Research Institute of Experimental and Clinical Medicine, 2 Timakova st., Novosibirsk, Russian Federation)
• Trifonova K.E. (State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Russian Federation)
• Fufaeva M.S. (Research Institute of Experimental and Clinical Medicine, 2 Timakova st., Novosibirsk, Russian Federation)
• Kretov E.I. (Meshalkin Siberian Federal Biomedical Research Center, 15 Rechkunovskaya st., Novosibirsk, Russian Federation)
• Mironov Y.V. (Nikolaev Institute of Inorganic Chemistry SB RAS, 3, Acad. Lavrentiev Ave., Novosibirsk, Russian Federation, Novosibirsk State University, 2 Pirogova Str., Novosibirsk, Russian Federation)
• Poveshchenko A.F. (Research Institute of Clinical and Experimental Lymphology, Branch of the ICG SB RAS, 2 Timakova st., Novosibirsk, Russian Federation)
• Lang K. (Institute of Inorganic Chemistry, Czech Academy of Sciences V.v.i., Husinec-Řež 1001, Řež, United States)
• Shestopalov M.A. (Research Institute of Experimental and Clinical Medicine, 2 Timakova st., Novosibirsk, Russian Federation, Research Institute of Clinical and Experimental Lymphology, Branch of the ICG SB RAS, 2 Timakova st., Novosibirsk, Russian Federation, Nikolaev Institute of Inorganic Chemistry SB RAS, 3, Acad. Lavrentiev Ave., Novosibirsk, Russian Federation, Novosibirsk State University, 2 Pirogova Str., Novosibirsk, Russian Federation)

• Scopus