Distribution and Resorption of Polymeric Microparticles in Visceral Organs of Laboratory Animals after Intravenous Injection

Описание

Тип публикации: статья из журнала

Год издания: 2009

Идентификатор DOI: 10.1007/s10517-010-0817-3

Ключевые слова: resorbable polyhydroxybutyrate, microparticles, intravenous injection, (14)C, visceral tissues, 14C, Intravenous injection, Microparticles, Resorbable polyhydroxybutyrate, Visceral tissues, carbon 14, microsphere, polyhydroxyaminobutyric acid, polymer, unclassified drug, animal experiment, animal tissue, article, biocompatibility, biodegradability, body growth, controlled drug release, controlled study, degradation kinetics, drug delivery system, drug dosage form, experimental animal, female, liver parenchyma, molecular weight, nonhuman, particle size, physical development, radioactivity, rat, spleen, tissue distribution, tissue structure, Animals, Animals, Laboratory, Carbon Radioisotopes, Female, Injections, Intravenous, Particle Size, Polymers, Rats, Rats, Wistar, Tissue Distribution, Viscera, Animalia

Аннотация: Microparticles obtained by using (14)C-labeled resorbable hydroxyaminobutyric acid polymer were injected into the caudal vein of laboratory animals without negative aftereffects for their growth and development and without changes in the macro- and microstructure of organs and tissues. The distribution of microparticles in the viscПоказать полностьюera and the dynamics of accumulation of carbon-containing polymer degradation products in the viscera were studied. The main targets for the particles are liver tissues, as well as renal and splenic tissues. The polymeric matrix of the microparticles is most actively destroyed in the spleen and liver. The presence of high-molecular-weight polymeric matrix in organs indicates the integrity of microparticles and the possibility of long-term ( up to 12 weeks) functioning of polymeric particles in vivo.

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Издание

Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Выпуск журнала: Vol. 148, Is. 5

Номера страниц: 789-793

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER

Авторы

  • Shishatskaya E.I. (Russian Acad Sci, Inst Biophys, Siberian Div, Moscow 117901, Russia)
  • Goreva A.V. (Russian Acad Sci, Inst Biophys, Siberian Div, Moscow 117901, Russia)
  • Voinova O.N. (Russian Acad Sci, Inst Biophys, Siberian Div, Moscow 117901, Russia)
  • Kalacheva G.S. (Russian Acad Sci, Inst Biophys, Siberian Div, Moscow 117901, Russia)
  • Volova T.G. (Russian Acad Sci, Inst Biophys, Siberian Div, Moscow 117901, Russia; Siberian Fed Univ, Inst Basic Biol & Biotechnol, Krasnoyarsk, Russia)

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