Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1007/s10517-016-3172-1

Ключевые слова: oxidative stress, redox regulation, breast adenocarcinoma, apoptosis, tumor progress

Аннотация: MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation withПоказать полностьюN-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.

Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Выпуск журнала: Vol. 160, Is. 3

Номера страниц: 364-367

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER

• Shakhristova E.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Stepovaya E.A. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Nosareva O.L. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Yakushina V.D. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Ivanov V.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Novitskii V.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Ryazantseva N.V. (Siberian Federal University)

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