Effect of microwave irradiation on arabinogalactan and its interaction with betulin diacetate

Описание

Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.14258/jcprm.2017041854

Ключевые слова: Arabinogalactan, Betulin diacetate, Complexation, Microwave irradiation, Solubility

Аннотация: Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this work, influence of microwave (MW) irradiation on the properties of AG and BDA anПоказать полностьюd their interaction in the aqueous suspension with formation of a water-soluble supramolecular complex was studied. It is shown that the MW heating of AG under hard conditions can lead to degradation of the biopolymer. The use of MW heating allowed significantly reducing the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under MW irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under MW irradiation similar to that formed by conventional heating. BDA-AG complex was isolated from a MW heated solution as a thin film, which may be a promising material for pharmaceutical applications.

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Издание

Журнал: Khimiya Rastitel'nogo Syr'ya

Выпуск журнала: Is. 4

Номера страниц: 73-79

ISSN журнала: 10295151

Издатель: Altai State University

Авторы

  • Malyar Yu.N. (Institute of Chemistry and Chemical Technology, SB RAS, FRC KSC SB RAS, Akademgorodok, 50-24, Krasnoyarsk, Russian Federation, Siberian Federal University, pr Svobodny, 79, Krasnoyarsk, Russian Federation)
  • Mikhailenko M.A. (Institute of Solid State Chemistry and Mechanochemistry, SB RAS, ul. Kutateladze, 18, Novosibirsk, Russian Federation)
  • Pankrushina N.A. (N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, pr. Lavrentieva, 9, Novosibirsk, Russian Federation)
  • Mikheev A.N. (Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, Russian Federation)
  • Kuznetsova S.A. (Institute of Chemistry and Chemical Technology, SB RAS, FRC KSC SB RAS, Akademgorodok, 50-24, Krasnoyarsk, Russian Federation, Siberian Federal University, pr Svobodny, 79, Krasnoyarsk, Russian Federation)
  • Shakhtshneider T.P. (Institute of Solid State Chemistry and Mechanochemistry, SB RAS, ul. Kutateladze, 18, Novosibirsk, Russian Federation, Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, Russian Federation)

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