Тип публикации: статья из журнала

Год издания: 2016

Идентификатор DOI: 10.1007/s10517-016-3397-z

Ключевые слова: beta-catenin, E-cadherin, thyroid cancer, ?-catenin

Аннотация: We compared the results of gene molecular and immunocytochemical studies of beta-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/beta-catenin complex leading to switchiПоказать полностьюng from adhesion function of beta-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin-beta-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.

Журнал: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Выпуск журнала: Vol. 161, Is. 2

Номера страниц: 288-291

ISSN журнала: 00074888

Место издания: NEW YORK

Издатель: SPRINGER

• Isaeva A.V. (Tomsk Research Institute of Oncology)
• Brynova O.V. (Moscow Municipal Oncological Hospital No. 62)
• Ryazantseva N.V. (Siberian Federal University)
• Litvinova L.S. (I. Kant Baltic Federal University)
• Pak Y.D. (Tomsk Regional Clinical Hospital)
• Zima A.P. (I. Kant Baltic Federal University)
• Saprina T.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Popov O.S. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Berezkina I.S. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Vasil'eva O.A. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Novitskii V.V. (Siberian State Medical University,Ministry of Health of the Russian Federation)
• Kasoyan K.T. (Russian Medical Academy of Postgraduate Education)
• Shabalova I.P. (Russian Medical Academy of Postgraduate Education)

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