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Improved Synthesis of 2-(1-Adamantyl)-4-bromophenol and 2-(1-Adamantyl)-4-bromoanisole, Intermediates in Adapalene Synthesis

Описание

Тип публикации: статья из журнала

Год издания: 2013

Идентификатор DOI: 10.1007/s11094-013-0931-4

Ключевые слова: adapalene, 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, 2-(1-adamantyl)-4-bromophenol, 2-(1-adamantyl)-4-bromoanisole, 1-adamantanol, 1-bromoadamantane, synthesis, alkylation, 2 (1 adamantyl) 4 bromoanisole, 2 (1 adamantyl) 4 bromophenol, bromine, unclassified drug, article, drug synthesis

Аннотация: A new simple and environmentally friendly synthetic method for 2-(1-adamantyl)-4-bromophenol that did not use catalysts and solvents was developed. A new simplified preparation method for 2-(1-adamantyl)-4-bromoanisole in one step instead of two was proposed. Both compounds are intermediates in the first and second synthetic steps Показать полностьюto 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene).

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Издание

Журнал: PHARMACEUTICAL CHEMISTRY JOURNAL

Выпуск журнала: Vol. 47, Is. 4

Номера страниц: 217-218

ISSN журнала: 0091150X

Место издания: NEW YORK

Издатель: SPRINGER

Персоны

  • Sokolenko V.A. (Institute of Chemistry and Chemical Technology,Siberian Branch of the Russian Academy of Sciences)
  • Svirskaya N.M. (Institute of Chemistry and Chemical Technology,Siberian Branch of the Russian Academy of Sciences)
  • Peterson I.V. (Institute of Chemistry and Chemical Technology,Siberian Branch of the Russian Academy of Sciences)
  • Rubailo A.I. (Siberian Federal University)

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